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Relationship between soluble amyloid beta and secretory phospolipase A2 to the progression of Alzheimer's disease

✍ Scribed by B.O. Pasaribu; A. Wijaya; A. Hamid

Book ID
119303158
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
89 KB
Volume
283
Category
Article
ISSN
0022-510X

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Elevated levels of zinc 2+ and copper 2+ are found chelated to the amyloid-beta-peptide (Ah) in isolated senile plaque cores of Alzheimer's disease (AD) patients. However, the precise residues involved in Zn 2+ ligation are yet to be established. We have used 1 H NMR and CD to probe the binding of Z