Relationship between renal succinoxidase activity and maximal transport rates of p-aminohippurate (TmPAH) in various representative vertebrates
✍ Scribed by Forster, Roy P. ;Goldstein, Leon
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1961
- Tongue
- English
- Weight
- 383 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0095-9898
No coin nor oath required. For personal study only.
✦ Synopsis
Interest in this problem arose from the fortuitous observation that kidneys of marine fishes maintained under laboratory conditions continue to excrete at essentially undiminished rates such actively transported organic acids as p-aminohippuric (PAH) and the phenolsulphonphthaleins (Forster, ' 5 3 ) despite the progressive drop in hematocrit to less than 5% which characteristically accompanies the attending diuresis and shift in the electrolytic composition of their body fluids during captivity (Forster and Berglund, '56). Since this transport process has been shown to be dependent upon tricarboxylic acid cycle-cytochrome system activity and aerobic phosphorylation (Forster and Taggart, '50; Taggart and Forster, ' 5 0 ) , the maintenance of maximal secretory rates might be due to an adaptive increase in one or more enzymes of the T.C.A. cycle. However, it was found that the activity of a representative T.C.A. cycle enzyme system, succinoxidase, was not significantly altered by reduced blood oxygen content. Comparative studies revealed a significant correlation between maximal renal succinoxidase activity and the maximal capacity of renal tubules of various species to transport PAH.