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Relationship between physicochemical properties, lipophilicity parameters, and local anesthetic activity of dibasic esters of phenylcarbamic acid

✍ Scribed by I. Malík; E. Sedlárová; J. Csöllei; F. Andriamainty; J. Čižmárik

Book ID: 111491046
Publisher: Versita
Year: 2007
Tongue: English
Weight: 482 KB
Volume: 61
Category: Article
ISSN: 0366-6352
DOI: 10.2478/s11696-007-0021-8

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✦ Synopsis

Abstract

The basic physicochemical properties, lipophilicity parameters of dibasic alkyloxy-substituted phenylcarbamic acids were estimated. For the prepared set of compounds the experimentally obtained solubility, acidity, and lipophilicity parameters were correlated with those computed using various computer programs based on the associative artificial neural network and fragmental methods. The results of pharmacological evaluation were used as entry data for the complex correlations.

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