Relationship between Ion Pair Geometries and Electrostatic Strengths in Proteins

Fluctuations between stabilizing and des

Fluctuations between stabilizing and destabilizing electrostatic contributions of ion pairs in conformers of the c-Myc-Max leucine zipper

✍ Sandeep Kumar; Ruth Nussinov 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 290 KB

In solution proteins often exhibit backbone and side-chain flexibility. Yet electrostatic interactions in proteins are sensitive to motions. Hence, here we study the contribution of ion pairs toward protein stability in a range of conformers which sample the conformational space in solution. Specifi