Relationship between Hemolytic Toxicity and Signal Intensity of Various Organotin Compounds by a Spin-labeling Technique
✍ Scribed by Takahiko Sato; Hideki Masumoto; Hisamitsu Nagase; Hideaki Kito; Miki Niikawa
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 74 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0268-2605
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✦ Synopsis
Various organotin compounds caused strong hemolysis of erythrocytes. To investigate the mechanism of hemolysis, spin-labeling techniques with electron spin resonance (ESR) spectroscopy were used and the relationship between hemolytic toxicity and signal intensity was investigated. Two kinds of spin-labeled stearic acid in which the paramagnetic center was located at different sites on the alkyl chain (5-and 12-doxyl-stearic acids; 5-and 12-NS) were used. It became clear that the decrease of ESR signal intensity was related to the hemolytic toxicity of the organotin compounds.