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Relationship between fibrin clot retraction and tumorigenesis in C3H/10T1/2 cells

✍ Scribed by B. Azzarone; D. Brouty-Boyé; A. MacIeira-Coelho

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
507 KB
Volume
28
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Fibrin clot retraction (FCR) was studied in C3H/10T1/ 2 murine fibroblasts. These cells were able to induce FCR with high efficiency during resting phase as well as during active growth. C3H/10/T1/2 cells which became tumorigenic after X‐irradiation lacked FCR activity. Non‐tumorigenic revertant clones regained the capacity to induce FCR, while revertants which progressively back‐reverted to the neoplastic state showed intermediate FCR activity. These unstable revertants, when again fully tumorigenic, completely lost FCR activity.

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