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Relationship between enzyme heterozygosity and quaternary structure

โœ Scribed by Robert D. Ward

Publisher
Springer
Year
1977
Tongue
English
Weight
751 KB
Volume
15
Category
Article
ISSN
0006-2928

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โœฆ Synopsis

The need for proteins to maintain particular quaternary structures constrains variability in amino acid sequence. Monomeric enzymes are then expected to be more variable than dimeric forms, which in turn are expected to be more variable than tetrameric forms. These predictions are confirmed by analysis of available data on enzyme variation. Theories relating enzyme heterozygosity to metabolic function are discussed in the light of these findings.

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