Relationship between enhancement of plasma level of aminopyrine by barbital and stomach emptying pattern
✍ Scribed by Shigeru Goto; Osami Tsuzuki; Sadao Iguchi
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- English
- Weight
- 314 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
The significantly increased plasma level of aminopyrine after simultaneous administration of barbital was recognized previously using rabbits. An increased rate of gastric emptying of aminopyrine induced by barbital could be considered as a likely reason for such a positive effect of barbital. A sample solution containing a known quantity of phenol red was given, and the total gastric content was withdrawn through a vinyl tube passed into the rabbit stomach at 0.5 and 2 hr. The calculated values from the measurement should provide precise information as to the state in the stomach. It was concluded that aminopyrine suppresses the transfer of phenol red to the duodenum, and simultaneously administered barbital can eliminate the effect of aminopyrine on the gastric emptying of phenol red and reduce the gastric emptying time of aminopyrine.
Keyphrases 0 Stomach emptying pattern-relationship to aminopyrine plasma level enhancement by barbital, rabbits 0 Barbitalinduced enhancement of aminopyrine plasma levels-relationship to stomach emptying pattern, rabbits 0 Aminopyrine plasma levels, barbital-induced enhancement-relationship to gastric emptying rates, phenol red transfer in duodenum, rabbits 0 Gastric emptying rates-relationship to barbital-induced increase of aminopyrine plasma levels, rabbits A To whom inquiries should be directed.