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Relationship between dose, effect, time, and biophasic drug levels

✍ Scribed by Victor F. Smolen; Ronald G. Barile; Theophanis G. Theophanous

Publisher
John Wiley and Sons
Year
1972
Tongue
English
Weight
368 KB
Volume
61
Category
Article
ISSN
0022-3549

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Computer simulations were performed to determine if the threshold dose of an infused drug (rather than the drug concentration in the biophase at onset of action) can be a suitable index for pharmacodynamic investigations as proposed by others. A two-compartment pharmacokinetic model with drug elimin