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Relationship Between Characteristics of Medications and Drug-Induced Liver Disease Phenotype and Outcome

✍ Scribed by Vuppalanchi, Raj; Gotur, Raghavender; Reddy, K. Rajender; Fontana, Robert J.; Ghabril, Marwan; Kosinski, Andrzej S.; Gu, Jiezhun; Serrano, Jose; Chalasani, Naga

Book ID
122111380
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
295 KB
Volume
12
Category
Article
ISSN
1542-3565

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The combination of high aminotransferases (hepatocellular injury) and jaundice has been reported to lead to a mortality rate of 10% to 50% for different drugs, a phenomenon known as "Hy's rule." However, Hy's rule has never been validated, and limited data exist on predictors for outcome in hepatoce