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Relationship between catecholamines and serotonin in sympathetic nerves of the rat pineal gland

โœ Scribed by Zweig, Mark ;Axelrod, Julius

Publisher
John Wiley and Sons
Year
1969
Tongue
English
Weight
724 KB
Volume
1
Category
Article
ISSN
0022-3034

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โœฆ Synopsis

Sympathetic nerves of the pineal gland contain both serotonin and norepinephrine. Inhibition of norepinephrine synthesis with a tyrosine hydroxylase inhibitor, a-methyl-p-tyrosine (aMPT) , causes an elevation of pineal serotonin. The administration of dopamine or norepinephrine blocks the elevation of pineal serotonin by aMPT. When sympathetic nerves to the pineal are interrupted aMPT no longer causes a rise in pineal serotonin. Tryptophan causes a marked increase in pineal serotonin: aMPT enhances and norepinephrine blocks this rise.

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