Although the measurement of total alkaline phosphatase activity in serum is a valid index to 8ssess the activity of Paget's disease of bone and to monitor treatment efficacy, this marker may lack sensitivity in some cases. Among the various markers of bone formation and resorption that have been dev
Relationship between biochemical markers of bone turnover and bone scintigraphic indices in assessment of Paget's disease activity
✍ Scribed by Luisa Alvarez; Pilar Peris; Francisca Pons; Nuria Guañabens; Ramón Herranz; Ana Monegal; José L. Bedini; Ramón Deulofeu; M. Jesús Martínez De Osaba; José Munoz-Gómez; Antonio M. Ballesta
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 765 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0004-3591
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We have compared the use of new markers of bone turnover in the assessment and treatment of Paget disease and made observations on the mechanisms of bone resorption. Urine hydroxyproline (Hyp) as a bone resorption marker and serum alkaline phosphatase (ALP) as a bone formation marker have traditiona