Relationship between binding affinity and functional activity of nociceptin/orphanin FQ
β Scribed by I.D Adapa; L Toll
- Book ID
- 114118324
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 566 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0143-4179
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The endogenous ligand for the orphan opioid receptor, orphanin FQ/nociceptin (OFQ), has recently been characterized. The OFQ peptide sequence contains paired basic amino acids, suggesting the possibility of posttranslational processing to a peptide containing the first 11 amino acids of the OFQ pept
The presence of pairs of basic amino acids within the orphanin FQ/Nociceptin (OFQ/N) sequence has raised the possibility that truncated versions of the peptide might be physiologically important. OFQ/N(1-11) is pharmacologically active in mice, despite its poor affinity in binding assays (K i ΟΎ 250