Long-term treatment with levodopa in Parkinson's disease results in the development of motor fluctuations, including reduced duration of antiparkinsonian action and involuntary movements, i.e., levodopa-induced dyskinesia. Cannabinoid receptors are concentrated in the basal ganglia, and stimulation
โฆ LIBER โฆ
Relationship among nigrostriatal denervation, parkinsonism, and dyskinesias in the MPTP primate model
โ Scribed by Donato A. Di Monte; Alison McCormack; Giselle Petzinger; Ann Marie Janson; Maryka Quik; William J. Langston
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 69 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0885-3185
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Previous studies in the MPTP-lesioned primate model of Parkinson's disease have demonstrated that alpha(2) adrenergic receptor antagonists such as idazoxan, rauwolscine, and yohimbine can alleviate L-dopa-induced dyskinesia and, in the case of idazoxan, enhance the duration of anti-parkinsonian acti