Relation of troponin T release kinetics to long-term clinical outcome in patients with acute ST segment elevation myocardial infarction treated with a percutaneous intervention
✍ Scribed by Apostolos J. Karavidas; Antony D. Vrachatis; Martin A. Alpert; Dimitris J. Nikas; Dionissios I. Achtypis; Evagellas P. Masrakas; Masolis G. Foukarakis; Toannis N. Fotiades; Apostolos A. Zacharoulis
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 77 KB
- Volume
- 56
- Category
- Article
- ISSN
- 1522-1946
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✦ Synopsis
The purpose of this study was to determine the relation of troponin T release kinetics to long-term clinical outcome in patients with an acute ST segment elevation myocardial infarction treated with a primary percutaneous intervention. One hundred and four patients with typical ischemic chest pain and > 1.5 mm ST segment elevation in > 2 contiguous leads underwent primary stenting (n = 60) or primary percutaneous transluminal coronary angioplasty (n = 44). Serum troponin T concentrations were obtained prior to and serially postintervention for 72 hr. Mean time to peak serum troponin T concentration was significantly longer in patients with cardiac death (P = 0.02), reinfarction (P = 0.007), target lesion reintervention (P = 0.03), and the composite of these events (13.2 +/- 5.3 vs. 9.3 +/- 4.0 hr; P < 0.0005). Multivariate analysis identified age, Killip class > 2, and time to peak serum troponin T concentration as independent predictors of long-term cardiac event-free survival. Thus, time to peak serum troponin T concentration independently predicts long-term cardiac event-free survival in patients with acute ST segment elevation myocardial infarction treated with a primary percutaneous intervention.