Relation of proliferative activity to survival in patients with gastric carcinoma

✍ Scribed by Yutaka Tonemura; Toru Kamata; Shigekazu Ooyama; Kazuo Sugiyama; Hironobu Kimura; Takeo Kosaka; Akio Yamaguchi; Itsuo Miyazaki

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 494 KB
• Volume: 43
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930430103

✦ Synopsis

The prognostic significance of proliferative activity in 167 gastric carcinomas was studied by means of an in vitro labeling method with bromodeoxyuridine (BrdU), using specimens obtained by endoscopic biopsy, and the results were correlated with conventional prognostic factors. The BrdU labeling indices (BrdU LI) varied from 2.1 to 45%. When the in vitro BrdU LI were plotted against in vivo BrdU LI, a significant correlation was found between in vitro and in vivo BrdU LI ( P < .01). These results show that the in vitro BrdU LI of specimens obtained by endoscopic biopsy indicate accurate proliferative activities of gastric cancers. The BrdU LI were closely correlated with nodal status, vessel invasion, and tumor size. With regard to the correlation of BrdU LI and prognosis, patients whose tumors had a high BrdU LI (BrdU greater than 10%) died significantly earlier than did those with low BrdU LI (BrdU LI less than 10%). When the BrdU LI and all the pathologic findings were entered simultaneously into the regression model, nodal status, tumor size, serosal involvement, and BrdU LI emerged as independent prognostic parameters. The present studies demonstrated the usefulness of the in vitro BrdUlabeling method to estimate the malignancy of gastric cancer preoperatively, and this method may be useful in designing the operative procedure and multimodal therapy for individual patients.