Changes in structural dynamics of the Gr
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Nico J. de Mol; M.Isabel Catalina; Marcel J.E. Fischer; Isabelle Broutin; Claudi
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Article
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2004
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Elsevier Science
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English
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Growth factor receptor-bound protein 2 (Grb2) is an extensively studied adaptor protein involved in cell signaling. Grb2 is a highly flexible protein composed of a single SH2 domain flanked by two SH3 domains. Here we report on the structural dynamic effects upon interaction of a phosphopeptide liga