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Relation of 5′-nucleotidase and phosphatase activities with immunophenotype, drug resistance and clinical prognosis in childhood leukemia

✍ Scribed by R. Pieters; D.R. Huismans; A.H. Loonen; G.J. Peters; K. Hählen; A. van der Does-van den Berg; E.R. van Wering; A.J.P. Veerman

Book ID
113239573
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
694 KB
Volume
16
Category
Article
ISSN
0145-2126

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Hypoxanthine-guanine phosphoribosyl-tran
Hypoxanthine-guanine phosphoribosyl-transferase in childhood leukemia: Relation with immunophenotype, in vitro drug resistance and clinical prognosis
✍ R. Pieters; D. R. Huismans; A. H. Loonen; G. J. Peters; K. Hählen; A. van der Do 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 555 KB

## Abstract Decreased activity of hypoxanthine‐guanine phosphoribosyltransferase (HGPRT), responsible for the conversion of 6‐mercaptopurine and 6‐thioguanine (6‐TG) to their cytotoxic nucleotides, may cause resistance to these thiopurines in experimental leukemic systems. The clinical significance