Relation between polyporphyrin distribution and blood brain barrier changes in the rat glioma model

✍ Scribed by Ying Ji; Diana L. Walstad; J. Tony Brown; Stephen K. Powers

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 598 KB
• Volume: 12
• Category: Article
• ISSN: 0196-8092
• DOI: 10.1002/lsm.1900120210

✦ Synopsis

Photofrinm (a polyporphyrin mixture) distribution in a rat glioma model was studied in relation to changes in the blood brain barrier (BBB). At selected intervals after intraperitoneal injection of Photofrinm, the concentration of polyporphyrins (PP) and Evans Blue Dye, an indicator of BBB permeability, were determined for tumor, brain adjacent to tumor (BAT), and normal brain tissue. Contrary to earlier reports of maximal accumulation at 4-24 hours, tumor levels of PP increased throughout the 96 hour measurement period. During the early stages of tumor development, PP uptake by tumor appeared to be less correlated to BBB disruption. We conclude that passive diffusion through an incompetent BBB does not completely explain PP accumulation in tumor tissue.