Relapse of precursor B-cell acute lymphoblastic leukemia as an isolated central nervous system mass lesion 9 years after initial diagnosis
✍ Scribed by Lowichik, A.; Bernini, J.C.; Tonk, V.; Ansarl, M.Q.; Rollins, N.K.; Winick, N.J.; Timmons, C.F.
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 635 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0098-1532
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✦ Synopsis
Seven years after completion of chemotherapy for acute lymphoblastic leukemia, diagnosed at the age of 5 years, a black female presented with signs o f increased intracranial pressure. Neuroimaging showed a large enhancing extra-axial occipital tumor mass. The resection specimen showed morphologic, cytogenetic, and immunopheno-typic features consistent with relapse of the primary leukemia. Bone marrow examination was negative for malignancy. The long duration of complete remission followed by the formation of a mass in the central nervous system are highly unusual features of recurrent acute lymphoblastic leukemia.