Rejection of tumors and metastases in fischer 344 rats following intratumor administration of killed corynebacterium parvum

✍ Scribed by Vilas V. Likhite

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: French
• Weight: 504 KB
• Volume: 14
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910140516

✦ Synopsis

Abstract

Killed Corynebacterium parvum vaccine was infiltrated into growing subcutaneous tumors (two antigenically different types) syngeneic to the Fischer 344 rats. In all these animals decrease in tumor size was followed by total and lasting disappearance. The protective response conferred as a result of intratumor C. parvum appeared to prevent progressive growth of potentially lethal pulmonary and visceral metastases. Animals which rejected their tumors showed an increased protection that was tumorspecific. Histological examination of tumors from rats exhibiting C. parvum‐mediated rejection revealed an intense non‐specific infiltration consisting mainly of macrophages with some lymphocytes. Of the groups of rats treated with surgical removal of the growing tumor, 30‐60% died with growing tumors and metastases. Suppressed rates of tumor growth and prolonged survival were observed in the group of rats treated with killed C. parvum subcutaneously 1 cm around and away from the growing tumors.