Reinforcement of tendon attachment to bioactive porous titanium by BMP-2-induced ectopic bone formation
✍ Scribed by Kazutaka So; Mitsuru Takemoto; Shunsuke Fujibayashi; Masashi Neo; Tadashi Kokubo; Takashi Nakamura
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 759 KB
- Volume
- 9999A
- Category
- Article
- ISSN
- 1549-3296
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✦ Synopsis
Abstract
Achieving a firm attachment between a tendon and a metal remains a major challenge in orthopedic surgery. In this study, we developed a simple model for evaluating the strength of this attachment using bioactive porous titanium, and confirmed whether bone morphogenic protein‐2 (BMP‐2) can be a help in achieving a firm attachment by ectopic bone formation. Rectangular plate‐shaped implants were soak‐loaded with BMP‐2 (B+ group) and were implanted within the patellar tendon of a rabbit. Implants without BMP‐2 (B− group) were used as controls, and they were harvested at 4 and 8 weeks postoperation for mechanical tests and for histological and histomorphometric study. The pull‐out failure load of the B+ group was significantly higher than that of the B− group and new bone was more prevalent within the pores and around the implants in the B+ group than in the B− group. The model used in this study was feasible for evaluating the tendon–metal attachment, and a combination of bioactive porous titanium and BMP‐2 was found to attach firmly to the tendon. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010