After swelling in hyposmotic solution, Ehrlich ascites tumor cells shrink towards their original volume. Upon restoration of isosmolality (300 mOsM) the cells initially shrink but subsequently recover volume. This regulatory volume increase (RVI) is completely blocked when [Na+]o or [Cl-]o is reduce
Regulatory volume increase in Ehrlich ascites tumor cells
β Scribed by Charles Levinson
- Book ID
- 115729547
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 689 KB
- Volume
- 1021
- Category
- Article
- ISSN
- 0005-2736
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π SIMILAR VOLUMES
## Abstract Ehrlich cells subjected to anisoosmolar media show very rapid volume changes. In hypertonic media they shrink. In hypotonic media they swell but the rapid initial swelling is followed by a regulatory shrinkage lasting ca. 30 minutes. Cells suspended in media with identical ionic concen
Abbreviations used: AACOCF 3 , an arachidonic acid (AA) analogue where the COOH-group of AA has been replaced by a COCF 3 -group; BAPTA, 1,2-bis-(2-carboxyethyl)-5-(and 6-)-carboxyfluorescein; BCECF-AM, 2Β΄,7Β΄-bis-(2-carboxyethyl)-5,6 carboxyfluorescein FLAP 5-lipoxygenase activating protein; ChTX, c