Regulatory T cells play a role in T-cell receptor CDR2 peptide regulation of experimental autoimmune encephalomyelitis
β Scribed by Abigail C. Buenafe; Shayne Andrew; Halina Offner; Arthur A. Vandenbark
- Book ID
- 108782978
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 512 KB
- Volume
- 135
- Category
- Article
- ISSN
- 0019-2805
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Based upon Blalock's complementary recognition approach, a complementary or antisense peptide (CP) was designed to the experimental autoimmune encephalomyelitis (EAE) epitope peptide, rat myelin basic protein (MBP) peptide 72-82. This peptide (EAE CP) was shown to have some sequence similarities to
Diabetogenic BDC2.5 CD4 T cells induce diabetes when injected into NOD.scid mice. However, when co-transferred with the OVA-specific DO11.10 CD4 T cells, BDC2.5 T cells failed to cause diabetes. This inhibition depended upon the stimulation of DO11.10 T cells only with soluble OVA, which skewed thei