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Regulatory T Cells in the Control of Transplantation Tolerance and Autoimmunity

✍ Scribed by Shuiping Jiang; Robert I. Lechler

Book ID
114423605
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
113 KB
Volume
3
Category
Article
ISSN
1600-6135

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## Abstract Sublethally irradiated, immunodeficient, C57BL/6 RAG‐2 gene‐deleted recipient mice reconstituted with T cell‐depleted bone marrow (BM) grafts frequently developed diarrhea, lost weight and showed signs of autoimmunity, dying between 4 and 7 weeks after reconstitution. Mice died despite