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Regulatory Proteins Enable the Kinesin Kip2 to Overpower Cytoplasmic Dynein

โœ Scribed by Roberts, Anthony J.; Goodman, Brian S.; Reck-Peterson, Samara L.


Book ID
122261935
Publisher
Biophysical Society
Year
2014
Tongue
English
Weight
41 KB
Volume
106
Category
Article
ISSN
0006-3495

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## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio