Regulatory properties of acetylcholine receptor. Evidence for two different inhibitory sites, one for acetylcholine and the other for a noncompetitive inhibitor of receptor function (procaine)

Probes for a Regulatory Site on the Nico

Probes for a Regulatory Site on the Nicotinic Acetylcholine Receptor-Channel. Synthesis of (±)-7-Debutylperhydrohistrionicotoxin, (±)-2-Depentyl-7-debutylperhydrohistrionicotoxin, and their Analogues

✍ Wieslaw Gessner; Kimio Takahashi; Bernhard Witkop; Arnold Brossi; Edson X. Albuq 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 German ⚖ 437 KB

## Abstract Reaction of glutarimide with pent‐4‐enylmagnesium bromide, followed by cyclization of intermediate ketoamide, and hydrolysis of the formates **10** and **13** led to the mixture of the hydroxylactams **11** __(cis)__ and **14** __(trans)__ which could be separated __via__ their benzenec