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Regulatory Mechanisms of Dopamine Biosynthesis at the Tyrosine Hydroxylase Step

โœ Scribed by MENEK GOLDSTEIN


Book ID
118721465
Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
291 KB
Volume
430
Category
Article
ISSN
0890-6564

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We have previously shown that the phorbol ester, TPA, which activates protein kinase C, causes, in PC12 cells, a transcriptional activation of tyrosine hydroxylase (TH), the key enzyme in catecholamine synthesis. The study has now been extended to examine the processes that underlie this transcripti