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Regulatory effects of mitochondrial lipids on glutamate dehydrogenase (NAD(P))

✍ Scribed by Jacques H. Julliard; Daniele C. Gautheron


Book ID
115902991
Publisher
Elsevier Science
Year
1972
Tongue
English
Weight
213 KB
Volume
25
Category
Article
ISSN
0014-5793

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The eects of methotrexate (MTX) on oxygen uptake by permeabilized HeLa cells were evaluated. MTX did not inhibit state III respiration when the oxidizable substrate was succinate, but when the substrates were 2-oxoglutarate or isocitrate the respiration decreased about 50 per cent at 1 . 0 mM concen