✦ LIBER ✦

Regulatory dendritic cells modulate immune responses via induction of T-cell apoptotic death

✍ Scribed by Xiaoyan Liang; Zongyou Chen; John J. Fung; Shiguang Qian; Lina Lu

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 115 KB
Volume: 26
Category: Article
ISSN: 0738-1085
DOI: 10.1002/micr.20205

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✦ Synopsis

Abstract

We describe a regulatory lymphoid dendritic cell (LDC) population propagated from mouse liver nonparenchymal cells (NPC) in IL‐3 and anti‐CD40 monoclonal antibody that are phenotypically mature, and induce T‐cell hyporesponsiveness by promoting T‐cell apoptotic death, which is partially caspase‐dependent, but is unlikely to be mediated by soluble factor(s). In vivo administration of liver LDC significantly prolonged the survival of vascularized cardiac allografts in an alloantigen‐specific manner. This is associated with enhanced T‐cell death in secondary lymphoid organs. © 2006 Wiley‐Liss, Inc. Microsurgery 26: 21–24, 2006.

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