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Regulatory Cancer Risk Assessment Based on a Quick Estimate of a Benchmark Dose Derived from the Maximum Tolerated Dose

✍ Scribed by David W. Gaylor; Lois Swirsky Gold


Book ID
115646844
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
47 KB
Volume
28
Category
Article
ISSN
0273-2300

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Determination of the maximum tolerated d
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## Abstract An escalating‐dose trial of idarubicin, used weekly for 3 doses in combination with vincristine, prednisone, and L‐asparaginase (VPLI), to reinduce remission of childhood ALL at first bone marrow relapse was conducted by the Childrens Cancer Study Group (CCSG). The maximum tolerated dos