Regulation of β-Adrenergic Receptors in Pediatric Heart Failure
✍ Scribed by Shelley Miyamoto; Carmen Sucharov; Penny Nelson; Rebecca Sobus; Brian Stauffer
- Book ID
- 116339513
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 174 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1532-8414
No coin nor oath required. For personal study only.
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## Cardiomyopathy Adrenergic receptor Cell signaling β-blocker Heart failure β-adrenergic receptor blockers have demonstrated significant survival benefit and have become standard therapy for adults with dilated cardiomyopathy, although their efficacy in pediatric patients is still unproven. Recen
In end-stage heart failure the expression of different myocardial regulatory proteins involved in the beta-adrenergic cAMP signalling pathway is altered. The downregulation of beta 1-adrenoceptors and their uncoupling from the effector as well as an increased expression of the inhibitory GTP-binding