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Regulation of α2β1-Mediated Fibroblast Migration on Type I Collagen by Shifts in the Concentrations of Extracellular Mg2+and Ca2+

✍ Scribed by John J. Grzesiak, George E. Davis, Daniel Kirchhofer and Michael D. Pierschbacher

Book ID
124823096
Publisher
Rockefeller University Press.
Year
1992
Tongue
English
Weight
770 KB
Volume
117
Category
Article
ISSN
0021-9525

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Activation of the α2β1 integrin-mediated
Activation of the α2β1 integrin-mediated malignant phenotype on type I collagen in pancreatic cancer cells by shifts in the concentrations of extracellular Mg2+ and Ca2+
✍ John J. Grzesiak; Michael Bouvet 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 755 KB

## Abstract The authors have previously demonstrated that α~2~β~1~ integrin‐mediated pancreatic cancer cell adhesion to Type I collagen is Mg^2+^‐dependent, inhibited by Ca^2+^, and that this integrin, purified from cell lysates using Type I‐collagen‐sepharose in Mg^2+^, can be eluted with Ca^2+^.