Regulation of voltage- and ligand-gated currents in rat hippocampal progenitor cellsin vitro

✍ Scribed by Sah, Dinah W. Y. ;Ray, Jasodhara ;Gage, Fred H.

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 432 KB
• Volume: 32
• Category: Article
• ISSN: 0022-3034
• DOI: 10.1002/(sici)1097-4695(199701)32:1<95::aid-neu9>3.0.co;2-9

✦ Synopsis

Growth medium and substrate regand NMDA, responses declined further; interestingly, ulate the proliferation and differentiation of neural kainate and gamma-aminobutyric acid (GABA) reprogenitor cells in vitro and the expression of cell sponses remained substantial. Moreover, the exprestype-specific histochemical markers. An important sion of functional channels and receptors in primary question is whether neural progenitor cells exhibit cultures of progenitor cells is up-regulated strongly voltage-and ligand-gated currents, features characby growth factors such as BDNF, and NT-3, whereas teristic of neurons, and whether these currents are sodium and calcium currents in passaged cultures reregulated differentially by growth conditions. Another spond to such growth conditions to a lesser extent. issue of interest is whether passaged progenitor cells, Kainate and GABA responses were present to a sigafter expansion with basic fibroblast growth factor nificant extent in passaged cultures, independent of (FGF-2), exhibit the same degree of plasticity as their growth condition. We conclude that environmental primary counterparts, or whether they are more comcues regulate different channels and receptors in dismitted to a particular phenotype. In primary cultures tinct ways in neural progenitor cells. ᭧ 1997 John of embryonic rat hippocampal progenitor cells,