## Abstract The matricellular glycoprotein, secreted protein acidic and rich in cysteine (SPARC), has complex biological activities and is important for lens epithelial cell function and regulation of cataract formation. To understand how SPARC influences lens epithelial cell activity and homeostas
Regulation of vascular morphogenesis by the matricellular protein SPARC
β Scribed by Motamed, Kouros; Helene Sage, E
- Book ID
- 109884777
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 732 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0085-2538
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Secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein that inhibits cellular adhesion and proliferation. In this study, we report the detection of SPARC in the interphase nuclei of embryonic chicken cells in vivo. Differential partitioning of SPARC was also noted in the cyt
## Abstract The matricellular SPARCβfamily member hevin (Sparcβlike 1/SPARCLβ1/SC1/Mast9) contributes to neural development and alters tumor progression in a range of mammalian models. Based on sequence similarity, we hypothesized that proteolytic digestion of hevin would result in SPARCβlike fragm