𝔖 Bobbio Scriptorium
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Regulation of transcription of MHC class II genes

✍ Scribed by Jeremy M Boss

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
611 KB
Volume
9
Category
Article
ISSN
0952-7915

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✦ Synopsis

Regulation of transcription of MHC class II genes Jeremy M Boss

Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1. One of the essential non-DNA-binding proteins, CIITA, appears to function as a limiting molecular switch that is responsible for the control of class II expression and the regulation of expression by interferon-T.

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