Regulation of TNF-Related Apoptosis-Inducing Ligand-Mediated Death-Signal Pathway in Human β Cells by Fas-Associated Death Domain and Nuclear Factor κB

Ebselen sensitizes glioblastoma cells to

Ebselen sensitizes glioblastoma cells to Tumor Necrosis Factor (TNFα)-induced apoptosis through two distinct pathways involving NF-κB downregulation and Fas-mediated formation of death inducing signaling complex

✍ Vivek Sharma; Richa Tewari; Ugir Hossain Sk; Christy Joseph; Ellora Sen 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 343 KB

## Abstract Resistance to tumor necrosis factor (TNFα)‐induced apoptosis in various cancer cells has been attributed to the activation of the transcription factor NF‐κB. Ebselen (2‐phenyl‐1,2‐benzisoselenazol‐3[2H]one)—a selenoorganic compound is known to prevent TNFα‐mediated NF‐κB activity. As gl