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Regulation of tissue inflammation by thrombin-activatable carboxypeptidase B (or TAFI)

✍ Scribed by Lawrence L.K. Leung; Timothy Myles; Toshihiko Nishimura; Jason J. Song; William H. Robinson


Book ID
116756901
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
417 KB
Volume
45
Category
Article
ISSN
0161-5890

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Thrombin-activatable carboxypeptidase B
✍ Shadi A. Sharif; Xiaoyan Du; Timothy Myles; Jason J. Song; Elizabeth Price; Davi πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 361 KB πŸ‘ 2 views

## Abstract ## Objective Osteopontin (OPN) is a proinflammatory cytokine that plays an important role in the pathogenesis of rheumatoid arthritis (RA). OPN can be cleaved by thrombin, resulting in OPN‐R and exposing the cryptic C‐terminal Ξ±4Ξ²1 and Ξ±9Ξ²1 integrin–binding motif (SVVYGLR). Thrombin‐ac