Regulation of the vav proto-oncogene by LKLF
โ Scribed by Diane J. Denkinger; Allison M. Cushman-Vokoun; Rodney S. Kawahara
- Book ID
- 117520641
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 340 KB
- Volume
- 281
- Category
- Article
- ISSN
- 0378-1119
No coin nor oath required. For personal study only.
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## Abstract __Vav__ is a guanine nucleotide exchange factor for the rho/rac GTPases that is upregulated in the embryo during the transition from primitive to definitive hematopoiesis. It is one of several genetic markers that correlates with the differentiation of the intraembryonic definitive hema
A novel human oncogene, designated VAV, has been recently characterized. This oncogene was generated by a rearrangement within the 5' coding sequences of a normal cellular gene, the VAV proto-oncogene. The normal VAV gene is specifically expressed in hematopoietic cells regardless of their different