Regulation of the transfected Na+/H+-exchanger NHE3 in MDCK cells by vasotocin
โ Scribed by C. Helmle-Kolb; F. Di Sole; J. Forgo; H. Hilfiker; C. M. Tse; V. Casavola; M. Donowitz; H. Murer
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 218 KB
- Volume
- 434
- Category
- Article
- ISSN
- 0031-6768
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๐ SIMILAR VOLUMES
Some epithelial cells have Na ฯฉ /H ฯฉ exchanger (NHE) activity in both apical and basolateral membranes. Amiloride-sensitive NHE-1 is generally identified in the basolateral membrane. The renal cell line, OK7a, targets amiloride-resistant NHE predominantly to the apical membrane. It is controversial
Several isoforms of Na / /H / exchanger (NHE-1-5) have been identified. LLC-PK1 clone 4 (CL4) expresses the amiloride-sensitive type of NHE predominantly in the basolateral membrane, which is believed to be NHE-1. It is not clear whether CL4 expresses NHE in the apical membrane and which side of NHE