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Regulation of the Rat SREBP-1c Promoter in Primary Rat Hepatocytes

โœ Scribed by Xiong Deng; Lauren M. Cagen; Henry G. Wilcox; Edwards A. Park; Rajendra Raghow; Marshall B. Elam


Book ID
115589191
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
243 KB
Volume
290
Category
Article
ISSN
0006-291X

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DNA synthesis in primary adult rat hepatocyte cultures was promoted by epidermal growth factor (EGF), arachidonic acid, and prostaglandins E2 and FLa (PGE2 and PGF2J. Growth promotion by EGF was blocked by 0.1 m M indomethacin and 1 m M aspirin, without affecting cell viability. If verapamil was pre