Regulation of the promoter for human immunoglobulin γ3 germ-line transcription and its interaction with the 3'α enhancer

Interaction of Smad3 with a proximal sma

Interaction of Smad3 with a proximal smad-binding element of the human α2(I) procollagen gene promoter required for transcriptional activation by TGF-β

✍ Shu-Jen Chen; Weihua Yuan; Sientay Lo; Maria Trojanowska; John Varga 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 264 KB 👁 1 views

Transcription of the alpha2(I) collagen gene (COL1A2) in fibroblasts is potently induced by transforming growth factor-beta (TGF-beta). Smad family proteins function as intracellular signal transducers for TGF-beta that convey information from the cell membrane to the nucleus. In the present study,