Regulation of the peroxisomal β-oxidation-dependent pathway by peroxisome proliferator-activated receptor α and kinases
✍ Scribed by Norbert Latruffe; Mustapha Cherkaoui Malki; Valérie Nicolas-Frances; Marie-Claude Clemencet; Brigitte Jannin; Jean-Pierre Berlot
- Book ID
- 113992396
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 450 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0006-2952
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## Abstract Studies indicate that peroxisome proliferator‐activated receptor‐β/δ (PPARβ/δ) can either attenuate or potentiate colon cancer. One hypothesis suggests that PPARβ/δ is upregulated by the adenomatous polyposis coli (APC)/β‐CATENIN pathway and a related hypothesis suggests that PPARβ/δ is
Enantiomers of a series of substituted analogs of 2-(4-chlorophenoxy) -acetic acid (CPAA) were synthesized and used to examine the influence of steric and structural parameters on peroxisome proliferation. The effects of these compounds were studied on the activation of the peroxisome proliferator-a