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Regulation of the Na,K-ATPase in MDCK cells by prostaglandin E1: a role for calcium as well as cAMP

✍ Scribed by Mary Taub; Maryanne Borsick; Janet Geisel; Keikantse Matlhagela; Trivikram Rajkhowa; Cheryl Allen

Book ID
116981056
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
627 KB
Volume
299
Category
Article
ISSN
0014-4827

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We studied the long-terms effects of interleukin-1beta (IL-1beta; 3 to 6 h) on alpha-(methylamino) isobutyric acid (MeAIB), a nonmetabolizable amino acid transported by system A. We found that IL-1beta induced a large decrease in MeAIB uptake by human osteoarthritic synovial cells and a concomitant