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Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone

✍ Scribed by Ralf Kubitz; Matthias Wettstein; Ulrich Warskulat; Dieter Häussinger

Book ID
118521739
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
480 KB
Volume
116
Category
Article
ISSN
0016-5085

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✍ Coen C. Paulusma; M. J. Kothe; Conny T. Bakker; Piter J. Bosma; Irene van Bokhov 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 829 KB

We have studied regulation of the multidrug resistance protein 2 (mrp2) during bile duct ligation (BDL) in the rat. In hepatocytes isolated after 16, 48, and 72 hours of BDL, mrp2-mediated dinitrophenyl-glutathione (DNP-GS) transport was decreased to 65%, 33%, and 33% of control values, respectively