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Regulation of the members of the mammalian heat shock factor family

✍ Scribed by Johanna K. Björk; Lea Sistonen


Book ID
111313664
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
325 KB
Volume
277
Category
Article
ISSN
1432-1327

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The activation of heat shock transcription factor-1 (HSF-1) after treatment of mammalian cells with stresses such as heat shock, heavy metals, or ethanol induces the synthesis of heat shock proteins. HSF-1 is phosphorylated at normal growth temperature and is hyperphosphorylated upon stress. We rece