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Regulation of the lysine biosynthesis inPichia guilliermondii

✍ Scribed by Heike Schmidt; Rüdiger Bode; Dieter Birnbaum

Book ID
104776548
Publisher
Springer Netherlands
Year
1989
Tongue
English
Weight
496 KB
Volume
56
Category
Article
ISSN
0003-6072

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✦ Synopsis

The regulatory properties of four enzymes (homocitrate synthase, alpha-aminoadipate reductase, saccharopine reductase, saccharopine dehydrogenase) involved in the lysine biosynthesis of Pichia guilliermondii were investigated and compared with the regulatory patterns found in other yeast species. The first enzyme of the pathway, homocitrate synthase, is feedback-inhibited by L-lysine. Some other amino acids (alpha-aminoadipate, glutamate, tryptophan, leucine) and lysine analogues are also inhibitors of one or more enzymes. It is shown that only the synthesis of homocitrate synthase is weakly repressed by L-lysine.

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