## Abstract Angiopoietins are ligands of the endothelial cell tyrosine kinase receptor Tie2. Angiopoietin‐1 (Ang‐1) is widely expressed in human normal adult tissues and promotes blood vessel maturation and stabilization by inducing Tie2 receptor phosphorylation. In contrast, the antagonistic ligan
✦ LIBER ✦
Regulation of the Lim-1 gene is mediated through conserved FAST-1/FoxH1 sites in the first intron
✍ Scribed by Minoru Watanabe; Martha L. Rebbert; Massimiliano Andreazzoli; Nobuhiro Takahashi; Reiko Toyama; Steven Zimmerman; Malcolm Whitman; Igor B. Dawid
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 292 KB
- Volume
- 225
- Category
- Article
- ISSN
- 1058-8388
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## Abstract ## BACKGROUND Previous reports indicate that Genistein, a naturally occurring isoflavonoid, exhibits strong antiangiogenic activity. The underlying mechanism of inhibition, however, remains unclear. Among the biologic effects of Genistein are the inhibition of tyrosine kinases and the