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Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes

✍ Scribed by Deepa R Hammaker, David L Boyle, Tomoyuki Inoue…

Book ID
120706489
Publisher
BioMed Central
Year
2007
Tongue
English
Weight
738 KB
Volume
9
Category
Article
ISSN
1478-6354

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## Abstract ## Objective Mitogen‐activated protein kinases (MAPKs) are activated by proinflammatory stimuli. MAPK phosphatases (MKPs), in particular MKP‐1, have been identified as endogenous negative regulators of MAPK activation. Since MAPKs are known to be important in rheumatoid arthritis (RA)