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Regulation of the human CHOP gene promoter by the stress response transcription factor ATF5 via the AARE1 site in human hepatoma HepG2 cells

✍ Scribed by Takashi Yamazaki; Asako Ohmi; Haruka Kurumaya; Kenji Kato; Takanori Abe; Hiroyuki Yamamoto; Noriko Nakanishi; Ryuichi Okuyama; Mariko Umemura; Toshikazu Kaise; Ryuya Watanabe; Yoshiko Okawa; Shigeru Takahashi; Yuji Takahashi


Book ID
116719838
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
898 KB
Volume
87
Category
Article
ISSN
0024-3205

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## Abstract The proinflammatory cytokine tumor necrosis factor (TNF) Ξ± is mainly produced in cells from the monocyte/macrophage lineage. TNFΞ± is also a key signaling molecule in the liver functioning as an important physiological and pathogenic mediator. In hepatocytes or human hepatoma cells TNFΞ±